This Supplement is Being Called ‘Nature’s Ozempic’ TikTok is abuzz over berberine, which some content creators on the platform are calling “nature’s Ozempic.” Berberine comes in powder and pill forms and is extracted from the stems/roots/bark of a number of plant species. Few studies have been done on berberine, but those that have been done found the supplement can improve insulin resistance, which can help reduce food cravings. Like other dietary supplements, berberine is not regulated by the U.S. Food and Drug Administration.